Prof. dr. Mathias Devreese

Prof. dr. Mathias Devreese graduated as a veterinarian in 2010 with great honors (Ghent University, Belgium). After graduation, he immediately started his PhD research at the Laboratory of Pharmacology and Toxicology regarding the efficacy of mycotoxin detoxifiers and their interaction with oral absorption of veterinary drugs. During his PhD research he performed a research stay of several months at the Department of Animal Biosciences at the University of Guelph (ON, Canada). After gaining his PhD in 2013, he obtained a post-doctoral research grant from the Research Foundation Flanders (FWO) to establish a juvenile piglet model for preclinical pediatric pharmacokinetic/pharmacodynamic research. He took a research sabbatical in 2016 to gain more in-depth knowledge regarding compartmental and population pharmacokinetic modeling at the Institute of Computational Comparative Medicine (ICCM) at Kansas State University (KS, USA). Since 2017 he is an EBVS™ European Specialist in Veterinary Pharmacology and Toxicology (ECVPT Diplomat). He is currently associate professor of veterinary pharmacology and therapeutics at Ghent University. 

Prof. dr. M. Devreese is a fellow of the American Academy of Veterinary Pharmacology and Therapeutics (AAVPT) and the European Association for Veterinary Pharmacology and Toxicology (EAVPT) and a member of the Animal Health Modeling and Simulation Society (AHMSS). He also serves as an associate editor for the journal BMC Veterinary Research (Pharmacology and Toxicology section) and Scientific Board member of the Journal of Veterinary Pharmacology and Therapeutics.

Main Research

The main research mission of the Laboratory of Pharmacology and Toxicology (Prof. dr. S. Croubels, Prof. dr. M. Devreese) consists of generating and communicating insights in in vivo ADME processes (absorption, distribution, metabolisation and excretion) and PK/PD modeling of human and veterinary drugs and toxins in a variety of animal species. The Laboratory is OECD GLP compliant for the conduct of in vivo ADME trials, pharmacokinetic modeling, safety studies, and bio-analysis of human and veterinary drugs. The Laboratory has over 20 years of experience in the development of analytical methodologies for the detection and quantification of xenobiotics (drugs, mycotoxins and their metabolites) in different biological samples such as plasma and tissues, using (UHP)LC-MS/MS and HR-LC-MS, and in pharmacokinetic (PK) and toxicokinetic (TK) modeling of these compounds.  The laboratory has 4 (UHP)LC-MS/MS instruments, 1 UHPLC-UV instrument and access to 3 HR-LC-MS instruments.

The research within the veterinary pharmacology group is related to optimization of antimicrobial dosage regimens for reduced resistance selection on the one hand, and the development of a juvenile piglet model as a pediatric preclinical model for PK/PD.

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