Small Animal Imaging
Infinity is the preclinical imaging research facility of Ghent University, providing multimodality-imaging services to national and international customers. It is a consortium of two major research groups: Medisip and the Laboratory for Radiopharmacy. A skilled and experienced scientific staff is running Infinity. Professors Christian Vanhove, Stefaan Vandenberghe, Filip De Vos and Roel Van Holen work together to streamline the research at Infinity. Additionally, professor Christian Vanhove is also responsible for the day-to-day functioning of the lab and the coordination of the partner research, either from within Ghent University, from private companies or from other universities. The major research domains of Infinity are neuromodulation (deep brain stimulation and trans-cranial magnetic stimulation), the use of imaging biomarkers to provide better tumor characterization, stress of the endoplasmatic reticulum (er stress), cardiovascular research to get a better understanding of the formation of aneurysms and plaque, and the development of ‘theranostic’ approaches by combining diagnosis and therapy.
But Infinity is about more than providing service to partners. The lab is actively involved in the multidisciplinary Research Platform on Inflammation and Immunity, called Group-ID. In 5 years time, Group-ID aims to be an international center of excellence in inflammation research, continuously attracting the best students and postdocs, have sufficient independent funding from the government and industry and become a core center of translational research in medicine.
Current research
- Combining optogenetics, chemogenetics, intracranial electroencephalography and functional magnetic resonance imaging to investigate abnormal functioning of brain networks during epileptogenesis
- MR biomarkers for cognitive training in mild traumatic brain injury in rats
Associated research
- Amino-acid PET based radiation treatment in an animal model for glioblastoma.
- Comparison of Ga68-PSMA and F18-PSMA in clinical and preclinical studies.
- Tracing xylem-transported 11C-labelled CO2 in trees: importance and contribution to the carbon metabolism.
Past research
- 18F and 99mTc labeled bile acid analogues to study (altered) hepatobiliary transporter function
- Continuous infusion micro positron emission tomography
- Development of LAT1-specific 18F amino acid PET tracers for the discrimination between low and high grade glioma
- Discriminating high-grade glioma from radiation necrosis in rats using kinetic modeling
- Effect of Cx-mimetic peptide administration on breast cancer brain metastasis development
- Evaluating bone structure surrounding dental implants
- Fast dynamic SPECT
- In-vitro analysis of extracted teeth
- Molecular MRI in early radiation injury detection
- Neural circuit mapping using simultaneous DBS-fMRI and opto-fMRI
- The impact of accelerated High Frequency repetitive Transcranial Magnetic Stimulation (HF-rTMS) on the serotonergic and dopaminergic system in a rat model of depression
- Visualization of the rat somatosensory network