Comparison of Ga68-PSMA and F18-PSMA in clinical and preclinical studies.

Prostate-specific membrane antigen (PSMA) is highly overexpressed in prostate cancer. Many PSMA analog radiotracers for PET/CT prostate cancer staging have been developed, such as ⁶⁸Ga-PSMA-11. This radiotracer has achieved good results in multiple clinical trials, but because of the superior imaging characteristics of ¹⁸F-fluoride, ¹⁸F-PSMA-11 was developed.  The aim of this study is to compare the prostate‐specific membrane antigen (PSMA)‐targeting characteristics of PSMA‐11, radiolabeled based on chelation of ¹⁸F‐AlF, to those of ⁶⁸Ga‐PSMA‐11 to image PSMA‐expressing xenografts.