Prof. Karolien De Bosscher
- Full Professor
- Head of the Translational Nuclear Receptor lab
Contact
Campus Ardoyen, Technologiepark-Zwijnaarde 75, 9052 Ghent
E-mail | LinkedIn | UGent Research Explorer | Orcid
Personalia
Biography
- 2013 - present: Professor - Ghent University
- 2002 - 2013: Postdoc - Ghent University
- 2000 - 2002: Postdoc - Cancer Research UK (London)
- 2000: PhD - Ghent University
- 1995: Master Biochemistry - Ghent university
Member of
- VIB-UGent Center for Medical Biotechnology
- Cancer Research Institute Ghent
- Nuclear Receptor Research Network
- UGent DiscoverE
Research tracks
Expertise
- Cellular signal transduction
- Anti-inflammatory and anti-cancer action mechanisms of nuclear receptors (GR, PPARs)
- Selective glucocorticoid receptor modulation
- Metabolic actions of GR and PPAR
- The benefit of nuclear receptor crosstalk mechanisms (GR,MR) in hematological cancers.
Publications
Key publications
- Novel assays monitoring direct glucocorticoid receptor protein activity exhibit high predictive power for ligand activity on endogenous gene targets. (2022) Biomedicine & Pharmacotherapy.
- How the glucocorticoid receptor contributes to platinum-based therapy resistance in solid cancer. (2021) Nature Communications.
- Improved Glucocorticoid Receptor Ligands: Fantastic Beasts, but How to Find Them? (2020) Frontiers in Endocrinology.
- Latest perspectives on glucocorticoid-induced apoptosis and resistance in lymphoid malignancies. (2020) Biochimica et Biophysica Acta-reviews on Cancer.
- Effect of combining glucocorticoids with Compound A on glucocorticoid receptor responsiveness in lymphoid malignancies. (2018) Plos One.