Heritable Thoracic Aortic Disease Lab

Heads

Improve the diagnosis, risk stratification, and treatment of patients with heritable thoracic aortic disease (HTAD)
Approach from different angles, integrating patient data and clinical studies with experiments in animal models, including both mice and zebrafish, to study mechanisms of disease and find new therapeutic targets
Aim to achieve more precise clinical management for HTAD with more reliable classification of genetic variants and a better understanding of genetic modifiers of disease

Study mechanisms of human cardiomyopathy in Marfan syndrome.
Clinical and molecular determinants of aging in congenital heart disease.
Use mouse models to study mechanisms leading to dissection and rupture of the thoracic aortic wall.
Investigate sex differences in the cardiovascular manifestations of HTAD.
Perform unbiased drug screening in a zebrafish model of Marfan syndrome to identify new potential therapeutic compounds