Angiopoetin-2 as Non-Invasive Biomarker and its Potential as Therapeutic Target for Pathological Angiogenesis and Inflammation in the Pathogenesis of Non-Alcoholic Steatohepatitis

Gut-Liver Immunopharmacology Unit

Project 2

Angiopoetin-2 as Non-Invasive Biomarker and its Potential as Therapeutic Target for Pathological Angiogenesis and Inflammation in the Pathogenesis of Non-Alcoholic Steatohepatitis.
Project in collaboration with Prof. Dr. Anja Geerts from the Hepatology Research Unit, dpt. Internal Medicine and Pediatrics.

Description

Non-alcoholic steatohepatitis (hepatic fat accumulation and inflammation) is characterized by endothelial dysfunction, a hallmark of pathological angiogenesis, and pro-inflammatory macrophage infiltration. Angiopoetin-2 is an angiogenic factor, produced by endothelial cells and activated macrophages, and is involved in dysfunctional vessel formation and pro-inflammatory macrophage polarization. Here, we will investigate the role of angiopoetin-2 in the pathogenesis of NASH and its potential as non-invasive biomarker and therapeutic target for non-alcoholic steatohepatitis.

Funding Ageny

 FWO

Contact

Lindsey Devisscher
Anja Geerts