Department of Basic and Applied Medical Sciences

Anesthesiology Finalized Projects

Anesthesiology and Perioperative Medicine

 

Finalized and published projects since 2016

 

  • Moerman A, Anssens S, Lapage K, Martens T, De Hert S, Near-infrared spectroscopy reveals transient impairment of microvascular reactivity, during severe acute anaphylaxis, J Cardiothor Vasc Anest 2016; 30: 149 – 153.
  • Leslie K, McIllroy D, Kasza J, Forbes A, Kurz A, Khan J, Meyhoff C, Allard R, Landoni G, Jara X, Lurati Buse G, Candiotti K, Lee HS, VanHelder T, Purayil W, De Hert S, Treschan T, Devereaux PJ, Neuraxial block and postoperative epidural analgesia: effects on outcomes in the POISE-2 trial, Br J Anaesth 2016; 116: 100 – 112.
  • Meier J, Filipescu D, Kozek-Langenecker S, Llau Pitarch J, Mallett S, Martus P, Matot I; ETPOS collaborators, Intraoperative transfusion practices in Europe, Br J Anaesth 2016; 116: 255 – 261
  • Moerman A, Meert F, De Hert S, Cerebral near-infrared spectroscopy in the care of patients during cardiological procedures: a summary of the clinical evidence, J Clin Monit Comput 2016; 30: 901 – 909
  • Vanpeteghem C, Moerman A, De Hert S, Perioperative hemodynamic management of carotid artery surgery, J Cardiothor Vasc Anesth 2016; 30: 491 – 500
  • Hendrickx JF, De Wolf AM, De Hert S , Reply to: preventing hypoxia, Eur J Anaesthesiol 2016; 33: 305
  • De Hert S, Cardiac troponins and volatile anesthetics in on-pump coronary surgery: how much longer do we need to state the obvious, Eur J Anaesthesiol 2016; 33: 393 – 395
  • Moerman A, Van Eeckhout C, Vanderstraeten K, De Somer F, Van Belleghem Y, De Hert S, The effect of hydroxyethyl starch 6% 130/0.4 compared with gelatin on microvascular reactivity, Anaesthesia 2016; 71: 798 – 805
  • Uhlig C, Bluth T, Schwarz K, Deckert S, Andreae M, De Hert S, Landoni G, Serpa Neto A, Schultz MJ, Pelosi P, Schmitt J, Gama de Abreu M, Effects of volatile anesthetics on mortality and postoperative pulmonary and extra-pulmonary complications in patients undergoing surgery: a systematic review and meta-analysis, Anesthesiology 2016; 124: 1230 – 1245
  • Wyffels PAH, Van Heuverswyn F, De Hert S, Wouters PF, Dynamic parameters in patients with atrial fibrillation: differentiating rhythm induced from ventilation induced variations in pulse pressure, Am J Physiol Heart and Circulatory Physiology 2016; 310: H194 – H200
  • Kolh P, De Hert S, De Rango P, The concept of risk assessment and being unfit for surgery, Eur J Vasc Endovasc Surg 2016; 51: 857 – 866
  • De Hert S, Moerman A, De Baerdemaeker L, Postoperative complications in cardiac patients undergoing noncardiac surgery, Curr Opin Crit Care 2016; 22: 357 – 364
  • Smit KF, Brevoord D, De Hert S, de Mol BA, Kerindongo RP, van Dieren S, Schlack WS, Hollmann MW, Weber NC, Preckel B, Effect of helium pre- or postconditioning on signal transduction kinases in patients undergoing coronary artery bypass graft surgery, J Translat Med 2016; 14: 294
  • International Surgical Outcomes Study group, Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries, Br J Anaesth, 2016; 117: 601 – 609
  • Bouchez S, Heyde B, Barbosa D, Vandenheuvel M, Huole H, Wang Y, D'hooghe J, Wouters P, In-vivo validation of a new clinical tool to quantify three-dimensional myocardial strain using ultrasound, Int J Cardiovasc Imag 2016; 32: 1707 – 14
  • Absalom AR, Glen JI, Zwart GJ, Schnider TW, Struys MM: Target-Controlled Infusion: a Mature Technology, Anesth Analg 2016; 122: 70-8
  • Carette R, Struys MM, De Wolf AM, Hendrickx JF: Not Really Triple Low? Anesthesiology 2016; 124: 1410-1
  • Colin P, Eleveld DJ, van den Berg JP, Vereecke HEM, Struys M, Schelling G, Apfel CC, Hornuss C: Propofol Breath Monitoring as a Potential Tool to Improve the Prediction of Intraoperative Plasma Concentrations, Clin Pharmacokinet 2016; 55: 849-859
  • Hannivoort LN, Vereecke HE, Proost JH, Heyse BE, Eleveld DJ, Bouillon TW, Struys MM, Luginbuhl M: Probability to tolerate laryngoscopy and noxious stimulation response index as general indicators of the anaesthetic potency of sevoflurane, propofol, and remifentanil, Br J Anaesth 2016; 116: 624-31
  • Kuhlmann L, Freestone DR, Manton JH, Heyse B, Vereecke HEM, Lipping T, Struys M, Liley DTJ: Neural mass model-based tracking of anesthetic brain states, Neuroimage 2016; 133: 438-456
  • Kuizenga MH, Vereecke HE, Struys MM: Model-based drug administration: current status of target-controlled infusion and closed-loop control, Curr Opin Anaesthesiol 2016; 29: 475-81
  • Schnider TW, Minto CF, Struys MM, Absalom AR: The Safety of Target-Controlled Infusions, Anesth Analg 2016; 122: 79-85
  • Shoushtarian M, Sahinovic MM, Absalom AR, Kalmar AF, Vereecke HE, Liley DT, Struys MM: Comparisons of Electroencephalographically Derived Measures of Hypnosis and Antinociception in Response to Standardized Stimuli During Target-Controlled Propofol-Remifentanil Anesthesia, Anesth Analg 2016; 122: 382-92
  • Struys MM, De Smet T, Glen JI, Vereecke HE, Absalom AR, Schnider TW: The History of Target-Controlled Infusion, Anesth Analg 2016; 122: 56-69
  • Ghijselings EI, De Cooman S, Carette R, Hendrickx JFA, Peyton P, De Wolf AM, Performance of an Active Inspired Hypoxic Guard, J Clin Monit Comput 2016; 30:63-8
  • Hendrickx JF, De Ridder SP, Dehouwer A, Carette R, De Cooman S, De Wolf AM, In vitro performance of prefilled CO2 absorbers with the Aisys®, J Clin Monit Comput 2016; 30:193-202
  • De Wolf AM, Hendrickx JF, Let's reduce fresh gas flow (seriously!) Minerva Anestesiol 2016; 82:149-50 , Carette R, De Wolf AM, Hendrickx JF, Automated gas control with the Maquet FLOW-i, J Clin Monit Comput 2016; 30:341-6
  • Dehouwer A, Carette R, De Ridder S, De Wolf AM, Hendrickx JF, Accuracy of inhaled agent usage displays of automated target control anesthesia machines, J Clin Monit Comput 2016; 30:539-43
  • Hendrickx JFA, De Hert S, De Wolf AM, Reply to letter by Zilberman P, Biro P: O2 delivery settings, Eur J Anaesthesiol 2016; 33:305
  • Hendrickx JF, De Wolf A, Skinner S, Journal of Clinical Monitoring and Computing 2015 end of year summary: anesthesia, J Clin Monit Comput 2016; 30:1-5
  • Hendrickx J, Peyton P, Carette R, De Wolf A, Inhaled anaesthetics and nitrous oxide: Complexities overlooked: things may not be what they seem, Eur J Anaesthesiol 2016; 33:611-9
  • De Medts R, Carette R, De Wolf AM, Hendrickx JFA, Sevoflurane or desflurane: which one is more expensive? Can J Anaesth, 2016; 63:358-9
  • Van Zundert TC, Hendrickx JF, De Witte JL, Wong DT, Cattano D, Brimacombe JR, Do mask aperture bars of extraglottic airway devices prevent prolapse of epiglottis causing airway obstruction? a randomized crossover trial in anesthetized adult patients.J Clin Anesth 2016; 31:231-7
  • Carette R, Struys MM, De Wolf AM, Hendrickx JF, Not Really Triple Low? Anesthesiology, 2016; 124:1410-1
  • Steenhaut K, Lapage K, Bové T, De Hert S, Moerman A, Evaluation of different near-infrared spectroscopy technologies for assessment of tissue oxygen saturation during a vascular occlusion test, J Clin Monit Comput 2017; 31: 1151 – 1158
  • Vereecke HE, Eleveld DJ, Colin P, Struys MM: Performance of the Eleveld pharmacokinetic model to titrate propofol in an obese Japanese patient population, Eur J Anaesthesiol 2016; 33: 58-9
  • Colin PJ, Hannivoort LN, Eleveld DJ, Reyntjens K, Absalom AR, Vereecke HEM, Struys M: Dexmedetomidine pharmacodynamics in healthy volunteers: 2, Haemodynamic profile, Br J Anaesth 2017; 119: 211-220
  • Eleveld DJ, Proost JH, Vereecke H, Absalom AR, Olofsen E, Vuyk J, Struys M: An Allometric Model of Remifentanil Pharmacokinetics and Pharmacodynamics, Anesthesiology 2017; 126: 1005-1018
  • Hara M, Masui K, Eleveld DJ, Struys M, Uchida O: Predictive performance of eleven pharmacokinetic models for propofol infusion in children for long-duration anaesthesia, Br J Anaesth 2017; 118: 415-423
  • Kuhlmann L, Manton JH, Heyse B, Vereecke HE, Lipping T, Struys MM, Liley DT: Tracking Electroencephalographic Changes Using Distributions of Linear Models: Application to Propofol-Based Depth of Anesthesia Monitoring, IEEE Trans Biomed Eng 2017; 64: 870-881
  • Sahinovic MM, Eleveld DJ, Miyabe-Nishiwaki T, Struys M, Absalom AR: Pharmacokinetics and pharmacodynamics of propofol: changes in patients with frontal brain tumours, Br J Anaesth 2017; 118: 901-909
  • Saunders R, Struys M, Pollock RF, Mestek M, Lightdale JR: Patient safety during procedural sedation using capnography monitoring: a systematic review and meta-analysis, BMJ Open 2017; 7: e01340
  • Struys M, Valk BI, Eleveld DJ, Absalom AR, Meyer P, Meier S, den Daas I, Chou T, van Amsterdam K, Campagna JA, Sweeney SP: a Phase 1, Single-center, Double-blind, Placebo-controlled Study in Healthy Subjects to Assess the Safety, Tolerability, Clinical Effects, and Pharmacokinetics-Pharmacodynamics of Intravenous Cyclopropyl-methoxycarbonylmetomidate (ABP-700) after a Single Ascending Bolus Dose, Anesthesiology 2017; 127: 20-35
  • van den Berg JP, Eleveld DJ, De Smet T, van den Heerik AVM, van Amsterdam K, Lichtenbelt BJ, Scheeren TWL, Absalom AR, Struys M: Influence of Bayesian optimization on the performance of propofol target-controlled infusion, Br J Anaesth 2017; 119: 918-927
  • Weerink MAS, Struys M, Hannivoort LN, Barends CRM, Absalom AR, Colin P: Clinical Pharmacokinetics and Pharmacodynamics of Dexmedetomidine, Clin Pharmacokinet 2017; 56: 893-913
  • De Hert S, Samama CM, Open access to research data: the two sides of the coin, Eur J Anaesthesiol 2017; 34: 1 – 3
  • Coppens M, Anssens S, Parashchanka A, Roelens K, Deschepper E, De Hert S, Wouters PF, Determination of the median effective dose (ED50 ) of spinal chloroprocaine in labour analgesia, Anaesthesia 2017; 72: 598 - 602
  • Koers L, Schlack WS, Hollmann MW, De Hert S, Preckel B, European implementation of the "2014 ESC/ESA guideline on non-cardiac surgery: cardiovascular assessment and management", Minerva Anestesiol 2017; 83: 457 - 464
  • Royston D, De Hert S, van der Linden J, Ouattara A, Zacharowski K, a special article following the relicence of aprotinin injection in Europe, Anaesth Crit Care Pain Med 2017; 36: 97 – 102
  • Habre W, Disma N, Virag K, et al, Incidence of svere critical events in paesdiatric anaesthesia (APRICOT): a prospective multicentre observational study in 261 hospitals in Europe, Lancet Respir Med 2017; 5: 412 – 425
  • Kahan BC, Koulenti D, Arvaniti K, et al, Critical Care admission following elective surgery was not associated with survival benefit: prospective analysis of data from 27 countries, Intensive Care Med 2017; 43: 971 – 979
  • Bluth T, Teichmann R, Kiss T et al, Protective intraoperative ventilation with higher versus lower levels of positive end-expiratory pressure in obese patients (PROBESE): study protocol for a randomized controlled trial, Trials 2017; 18: 202
  • LAS VEGAS investigators, Epidemiology, practice of ventilation and outcome for patients at increased risk of postoperative pulmonary complications: LAS VEGAS – an observational study in 29 countries, Eur J Anaesthesiol 2017; 34: 492 – 502
  • Vandenbulcke L, Lapage KG, Vanderstraeten KV, De Somer FM, De Hert SG, Moerman AT, Microvascular reactivity monitored with near-infrared spectroscopy is impaired after induction of anaesthesia in cardiac surgery patients: an observational study, Eur J Anaesthesiol 2017; 34: 688 – 694
  • McConnell P, Kaufman N, De Hert S, Samama MC, Molnar Z, Einav S, Research ethics committee approval as reported for abstracts submitted to the annual Euroanaesthesia meeting, Eur J Anaesthesiol 2017; 34: 824 – 830
  • Mauermann E, De Hert S, Dell-Kuster S, Filipovic M, Howell S, Ionescu D, Seeberger MD, Szczeklik W, Lurati Buse GAL, Re-evaluation of perioperative cardiac risk (the MET REPAIR study), Eur J Anaesthesiol 2017; 34: 709 – 712
  • Moerman A, De Hert S, Recent advances in cerebral oximetry, Assessment of cerebral autoregulation with near-infrared spectroscopy: myth or reality?, F1000Res 201; 6: 1615
  • International Surgical Outcomes Study (ISOS) group, The surgical safety checklist and patient outcomes after surgery: a prospective observational cohort study, systematic review and meta-analysis, Br J Anaesth 2018; 120: 146 – 155
  • De Hert S, Moerman A, Anesthetic Preconditioning: Have We Found the Holy Grail of Perioperative Cardioprotection?, J Cardiothorac Vasc Anesth 2018; in press
  • Neskovic AN, Skinner H, Price S, Via G, De Hert S, Stankovic I, Galderisi M, Donal E, Muraru D, Sloth E, Gargani L, Cardim N, Stefanidis A, Cameli M, Habib G, Cosyns B, Lancellotti P, Edvardsen T, Popescu BA; the 2016–2018 EACVI Scientific Documents Committee, Focus cardiac ultrasound core curriculum and core syllabus of the European Association of Cardiovascular Imaging, Eur Heart J Cardiovasc Imaging 2018; 19: 475 – 481
  • De Hert S, Staender S, Fritsch G, Hinkelbein J, Afshari A, Bettelli G, Bock M, Chew MS, Coburn M, De Robertis E, Drinhaus H, Feldheiser A, Geldner G, Lahner D, Macas A, Neuhaus C, Rauch S, Santos-Ampuero MA, Solca M, Tanha N, Traskaite V, Wagner G, Wappler F, Pre-operative evaluation of adults undergoing elective noncardiac surgery: Updated guideline from the European Society of Anaesthesiology, Eur J Anaesthesiol 2018; 35: 407 – 465
  • De Hert S, Burnout among anesthesiologists: it's time for action, J Cardiothor Vasc Anesth 2018; in press
  • Ceulemans A, De Looze D, Van de Putte D, Stiers E, Coppens M, High post-operative pain scores despite multimodal analgesia in ambulatory anorectal surgery: a prospective cohort study, Acta chirurgica Belgica 2018: 1-7
  • Herbelet S, Herregods L, Coppens M, Exploring strategies to reduce time span to bystander CPR in sudden cardiac arrest based on the mechanism of the witness acute stress response, Resuscitation 2018; 131: e7-e8
  • Snauwaert E, Van Biesen W, Raes A, et al, Concentrations of representative uraemic toxins in a healthy versus non-dialysis chronic kidney disease paediatric population, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2018; 33: 978-86
  • Van Caelenberg E, De Regge M, Eeckloo K, Coppens M, Analysis of failed discharge after ambulatory surgery: unanticipated admission, Acta chirurgica Belgica 2018: 1-7
  • Vandekerckhove M, Van Droogenbroeck B, De Loose M, et al, Development and validation of a standardized double-blind, placebo-controlled food challenge matrix for raw hazelnuts, Clinical and translational allergy 2018; 8: 3
  • Barends CRM, Absalom AR, Struys M: Drug selection for ambulatory procedural sedation, Curr Opin Anaesthesiol 2018, in press
  • Colin PJ, Jonckheere S, Struys M: Target-Controlled Continuous Infusion for Antibiotic Dosing: Proof-of-Principle in an In-silico Vancomycin Trial in Intensive Care Unit Patients, Clin Pharmacokinet 2018
  • Colin PJ, Kuizenga MH, Vereecke HEM, Struys M: Pharmacokinetic Pharmacodynamic Perspective on the Detection of Signs of Neural Inertia in Humans, Anesthesiology 2018; 129: 373-375
  • Eleveld DJ, Colin P, Absalom AR, Struys M: Corrigendum to "Pharmacokinetic-pharmacodynamic model for propofol for broad application in anaesthesia and sedation" [Br J Anaesth 2018; 120: 942-959], Br J Anaesth 2018; 121: 519
  • Eleveld DJ, Colin P, Absalom AR, Struys M: Pharmacokinetic-pharmacodynamic model for propofol for broad application in anaesthesia and sedation, Br J Anaesth 2018; 120: 942-959
  • Kalmar AF, Allaert S, Pletinckx P, Maes JW, Heerman J, Vos JJ, Struys M, Scheeren TWL: Phenylephrine increases cardiac output by raising cardiac preload in patients with anesthesia induced hypotension, J Clin Monit Comput. 2018; 32: 969-976
  • Kuizenga MH, Colin PJ, Reyntjens K, Touw DJ, Nalbat H, Knotnerus FH, Vereecke HEM, Struys M, Test of neural inertia in humans during general anaesthesia, Br J Anaesth 2018; 120: 525-536
  • Sahinovic MM, Struys M, Absalom AR: Clinical Pharmacokinetics and Pharmacodynamics of Propofol, Clin Pharmacokinet 2018, in press
  • Valk BI, Absalom AR, Meyer P, Meier S, den Daas I, van Amsterdam K, Campagna JA, Sweeney SP, Struys M: Safety and clinical effect of i.v, infusion of cyclopropyl-methoxycarbonyl etomidate (ABP-700), a soft analogue of etomidate, in healthy subjects, Br J Anaesth 2018; 120: 1401-1411
  • Hendrickx JFA, De Wolf AM, Skinner S, Journal of clinical monitoring and computing 2017 end of year summary: anesthesia, J Clin Monit Comput 2018; 32:207-211
  • De Medts R, Carette R, De Wolf AM, Hendrickx JFA, Desflurane usage during anesthesia with and without N2O using FLOW-i Automated Gas Control with 3 different wash-in speeds, J Clin Monit Comput 2018; 32:763-769
  • Omer M, Hendrickx JFA, De Ridder S, De Houwer A, Carette R, De Cooman S, De Wolf AM, In Vitro Performance of Prefilled CO2 Absorbers with the Zeus®, J Clin Monit Comput 2018; 32:799-806,