Cracking the code of bovine oocytes: how miRNAs, mRNAs, and epigenetics shape oocyte maturation
- Promovendus/a
- Camilla, Benedetti
- Faculteit
- Faculteit Diergeneeskunde
- Vakgroep
- Vakgroep Interne Geneeskunde, Voortplanting en Populatiegeneeskunde
- Curriculum
- Camilla Benedetti was born on September 20th, 1994 in Atessa, Italy. She earned a bachelor’s degree in Biology at the University of Perugia (Italy) in 2017 and a Master’s degree in Reproductive Biotechnology at the University of Teramo in 2019 with an honorable mention. That same year, she participated in an Erasmus+ program at the Hull York Medical School (HYMS) in the United Kingdom, where she specialized in the in vitro production of bovine embryos.
- Academische graad
- Doctor in de diergeneeskundige wetenschappen
- Taal proefschrift
- Engels
- Promotor(en)
- Prof. dr. Ann Van Soom, Faculty of Veterinary Medicine, UGent - Prof. dr. Katrien Smits, Faculty of Veterinary Medicine, UGent - Dr. Krishna Pavani Faculty of Veterinary Medicine, UGent
Korte beschrijving
Over her lifetime, a female mammal ovulates only a small fraction of the oocytes present in her ovaries at birth. In vitro maturation (IVM) provides an opportunity to utilize this largely untapped biological resource. While IVM is routinely employed for in vitro embryo production in domestic animals, particularly cattle, it is not that common in human assisted reproductive technology (ART). Achieving successful oocyte maturation in vitro remains challenging, with many immature oocytes failing to progress to the blastocyst stage. Research indicates that the initial quality of the oocyte is the primary determinant of its potential to develop into a blastocyst. Yet, special attention needs to be paid to the IVM environment as this might affect oocyte transcriptome and epigenetic marks, further impacting the oocyte’s competence to develop into an embryo and produce healthy offspring later. Therefore, studying the factors that shape oocyte competence in relation to both the follicular environment and the conditions during maturation is fundamental to enhancing IVM protocols and the success rates of ART
Praktisch
- Datum
- Maandag 30 september 2024, 17:00
- Locatie
- Auditorium D, Salisburylaan 133, 9820 Merelbeke
No registration is required. However, if you would like to attend the reception, please register as soon as possible and before 20/09/2024 by emailing camilla.benedetti@ugent.be